讲座预告 > 化学与分子工程学院

讲座主标题: 【兴大报告437】Chemical biology of O-GlcNAc: enzyme mechanisms to chemical probes       希望录制
讲座人: Professor David Vocadlo,Simon Fraser University Burnaby, BC, Canada
讲座地点: 化学楼A204-206
讲座开始时间: 2014-05-23 15:30:00
讲座结束时间: 2014-05-23 01:00:00
讲座内容介绍:

O-linked N-acetylglucosamine (O-GlcNAc) is an abundant form of protein O-glycosylation found in the nucleus and cytoplasm of multicellular eukaryotes. This post-translational modification is found on hundreds of proteins yet is regulated by only two enzymes; O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). O-GlcNAc levels in cells respond to changes in glucose availability and in some cases can influence protein phosphorylation. Accordingly, O-GlcNAc has been implicated in various essential biological processes. Inappropriate regulation of O-GlcNAc has been proposed to play roles in diseases ranging from cancer to Alzheimer's. Here I discuss our research focused on understanding the substrate specificities and catalytic mechanisms of OGT and OGA, as well as the exploitation of these insights to design probes of these enzymes that are active in cells and tissues. I will also discuss how these tools have enabled us to interrogate the functional roles of O-GlcNAc in various biological models including transgenic Alzheimer mice.

 











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