预告信息 讲座视频 讲座海报
讲座主标题 :
Sensing and Signaling DNA Damage by the Checkpoint Pathways
讲座人 :
Lee Zou
讲座地点 :
北京大学邓祐才报告厅
讲座开始时间 :
2015-06-18 13:00:00
讲座人介绍 :

讲座内容介绍 :

Cancer is a complex disease associated with genetic and epigenetic alterations in the genome. To prevent these detrimental alterations, cells have evolved an intricate signaling network, called the checkpoint, to detect and signal problems in the genome. During cancer development, the activation of oncogenes and loss of tumor suppressors leads to genomic instability, rendering cancer cells addicted to specific checkpoint signaling proteins to survive. The Zou laboratory is particularly interested in understanding how the checkpoint detects DNA damage and genomic instability, and how the checkpoint can be targeted in cancer therapy. Our current studies are focused on the activation of ATR and ATM, the master sensor kinases of two major checkpoint pathways. Furthermore, we are developing new strategies to exploit the genomic instability and checkpoint addiction of different cancer cells in targeted cancer therapy.

欢迎各位老师同学积极参加!